Who portrays Mrs. Wheeler Wheeler? What actress assumes the role of Karen Wheeler in the show? Whom is the performer behind Karen Wheeler? Karen is portrayed by who? Which actor plays the character of Karen Wheeler on the show? Whom is the talent personifying Karen the mother's character to life? What actor takes on the role of Karen Wheeler in the television show? Whoever takes on the part of Karen Mrs. Wheeler? Who is the talented individual enacting Karen the mother on the show? What actress incarnates the character of Karen Wheeler to the screen?